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Power Calculator for Repeated-Low Dose Challenge Studies
This calculator computes the statistical power of a randomized controlled repeated-low dose challenge study in non-human primates given the inputs provided. Power is for testing the null hypothesis that the relative risk (vaccine group vs control group) of infection per challenge is one versus the alternative hypothesis that the relative risk equals the input value. For a detailed description of the method see:
MG Hudgens, PB Gilbert, JR Mascola, CD Wu, DH Barouch, SG Self. Power to Detect the Effects of HIV Vaccination in Repeated Low-Dose Challenge Experiments. Journal of Infectious Diseases, 200(4):609-613, 2009.
TL Nolen, MG Hudgens, PK Sen, GG Koch. Analysis of repeated low‐dose challenge studies. Statistics in Medicine, 34(12), pp.1981-1992, 2015.