HPTN 052 Study: 2011 Science's Breakthrough of the Year HPTN 052 Study Materials

  • Select Publications:

    1. HPTN 052 Team (2011), Treatment is Prevention: The Proof is Here, 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy.

    2. M. Cohen, Y. Chen, M. McCauley, T. Gamble, M. Hosseinipour, N. Kumarasamy, J. Hakim, J. Kumwenda, B. Grinsztejn, J. Pilotto, S. Godbole, S. Mehendale, S. Chariyalertsak, B. Santos, K. Mayer, I. Hoffman, S. Eshleman, E. Piwowar-Manning, L. Wang, J. Makhema, L. Mills, G. de Bruyn, I. Sanne, J. Eron, J. Gallant, D. Havlir, S. Swindells, H. Ribaudo, V. Elharrar, D. Burns, T. Taha, K. Nielsen, D. Celentano, M. Essex, T. Fleming, and the HPTN 052 Protocol Team (2011), Prevention of HIV-1 Infection with Early Antiretroviral Therapy, New England Journal of Medicine, 365: 493-505.

    3. M. Cohen, Y. Chen, T, Fleming, for the HPTN 052 Team (2011) Author/Editor Response: Prevention of HIV-1 Infection with Antiretroviral Therapy. New England Journal of Medicine, 365: 1934-1935.

    4. S. Eshleman, S. Hudelson, A. Redd, L. Wang, R. Debes, Y. Chen, C. Martens, S. Ricklefs, E. Selig, S. Porcella, S. Mushaw, S. Ray, E. Piwowar-Manning, M. McCauley, M. Hosseinipour, J. Kumwenda, J. Hakim, S. Chariyalertsak, G. de Bruyn, B. Grinsztejn, N. Kumarasamy, J. Makhema, K. Mayer, J. Pilotto, B. Santos, T. Quinn, M. Cohen, and J. Hughes (2011), Analysis of genetic linkage of HIV from couples enrolled in the HIV Prevention Trials Network 052 trial, Journal of Infectious Disease, 204:1918-26.

    5. Y. Chen, B. Masse, L. Wang, S.-S. Ou, X. Li, D. Donnell, M. McCauley, T. Gamble, H. Ribauldo, M. Cohen, and T. Fleming (2012), Statistical considerations for the HPTN 052 study to evaluate the effectiveness of early versus delayed antiretroviral strategies to prevent sexual transmission of HIV-1 in serodiscordant couples, Contemporary Clinical Trials, 33(6): 1280-1286.

    6. R. Walensky, E. Ross, N. Kumarasamy, R. Wood, F. Noubary, D. Paltiel, Y. Nakamura, S. Godbole, R. Panchia, I. Sanne, M. Weinstein, E. Losina, K. Mayer, Y. Chen, L. Wang, M. McCauley, T. Gamble, G. Seage, and M. Cohen (2013) Cost-effectiveness of HIV treatment as prevention in serodiscordant couples, New England Journal of Medicine, 369: 1715-1725.

    7. B. Grinsztejn, M. Hosseinipour, H. Ribaudo, S. Swindells, J. Eron, Y. Chen, L. Wang, S. Ou, M. Anderson, M. McCauley, T. Gamble, N. Kumarasamy, J. Hakim, J. Kumwenda, J. Pilotto, S. Godbole, S. Chariyalertsak, M. de Melo, K. Mayer, S. Eshleman, E. Piwowa-Manning, J. Makhema, L. Mills, R. Panchia, I. Sanne, J. Gallant, I. Hoffman, T. Taha, K. Mielsen-Saines, D. Celentano, M. Essex, D. Havlir, and M., Cohen (2014) Effects of early versus delayed initiation of antiretroviral therapy on HIV clinical outcomes: results from the HPTN 052 trial. The Lancet Infectious Disease, 14(4): 281-290.
  • Study Materials:

    1. HIV Prevention Trials Network, HPTN 052 Study

    2. HPTN Press Release, Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052)

    3. NIH/NIAID Press Release, Treating HIV-infected People with Antiretrovirals Protects Partners from Infection

    4. WHO UNAIDS Press Release, Groundbreaking trial results confirm HIV treatment prevents transmission of HIV

    5. PEPFAR Statement, Statement by Ambassador Eric Goosby, U.S. Global AIDS Coordinator, U.S. Department of State, on the HPTN 052 Research Findings
  • In the News:

    1. Science, Breakthrough of the Year, 2011

    2. Aidsmap, Treatment is prevention: HPTN 052 study shows 96% reduction in transmission when HIV-positive partner starts treatment early

    3. The New York Times, Early H.I.V. Therapy Sharply Curbs Transmission

    4. The Washington Post, HIV drugs sharply cut risk of transmission

    5. The Wall Street Journal, Scientists See Breakthrough in the Global AIDS Battle

    6. Associate Press, Earlier HIV therapy protects against virus spread

    7. US News and World Report, Early HIV Drug Therapy Protects Sex Partners From Virus

    8. The Economist, AIDS: At last, the good news

    9. China Daily 中国日报(英文), 'Game-changer' in fight against AIDS

    10. 科学时报, HIV早期治疗可有效防止病毒在异性间传播

    11. 健康报, 早服抗艾药可大幅降低伴侣感染率

    12. 人民网, 抗逆转录病毒药可大幅降低艾滋病病毒传染率

    13. 中国时报, 及早治愛滋 傳染力大降低

    14. Forbes China 福布斯(中文), 美国预防艾滋病研究获得重大发现

    15. BBC, Anti-retroviral drugs 'help reduce' HIV transmission

    16. Reuters, Early drug treatment greatly cuts spread of HIV

    17. CBS, Major breakthrough in HIV prevention

    18. CNN, Taking HIV drugs earlier could curb new infections

    19. MSNBC, Starting HIV meds quickly helps protect partner

    20. NPR, Early Drug Treatment For HIV Slashes Infection Risk

    21. The Body, Treating HIV-Infected People With Antiretrovirals Significantly Reduces Transmission to Partners


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    Last modified: December, 2011